鏀惰棌-鍋ュ悍緗戜細鍛樿闂褰?/h3>

緗戦〉鏍囬錛?

娉ㄥ唽鍋ュ悍緗戠敤鎴?/h3>

鐢?鎴?鍚嶏細
鑱?緋?浜猴細
鎬?nbsp; 鍒細
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鐢靛瓙閭錛?/th>
閭楠岃瘉鐮侊細
鍥哄畾鐢佃瘽錛?/th>
浼?nbsp; 鐪燂細
鎵?nbsp; 鏈猴細
鍗曚綅鍚嶇О錛?/th>
閫氫俊鍦板潃錛?/th>
棣栭€夋爮鐩細
鎴戝凡緇忚鐪熼槄璇誨茍鍚屾剰銆婂仴搴風綉鏈嶅姟鏉℃銆?/a>

鎵懼洖瀵嗙爜

  • 1.閫夋嫨鎵懼洖鏂瑰紡
  • 2.紜楠岃瘉淇℃伅
  • 3.淇敼瀵嗙爜
  • 4.淇敼鎴愬姛
  • 鎵懼洖鏂瑰紡錛?/span>
  • 鐢?鎴?鍚嶏細
  • 鎵嬫満鍙風爜錛?/span>

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涓浗鍖昏嵂甯傚満淇℃伅鏈堟姤錛?023騫?3鏈堬級

浣滆€咃細yuanxc   鏉ユ簮錛氭湰绔欏師鍒?nbsp;   鐐瑰嚮鏁幫細0    鏇存柊鏃墮棿錛?023-3-21 10:52:09

[鍏抽敭瀛梋錛?/font> 涓浗鍖昏嵂甯傚満淇℃伅鏈堟姤

鍋ュ悍緗戣錛?/FONT>

鏈湡瀵艱

浼佷笟鍔ㄦ€?/span>

3鏈?/span>10鏃ワ紝涓界彔鍖昏嵂鍙戝竷鍏憡錛屽叕鍙鎬簬2023騫?/span>3鏈?/span>10鏃ヤ笌Onconic Therapeutics Inc.,( Onconic) 絳劇講浜嗐€婃巿鏉冭鍙崗璁€嬨€傛牴鎹崗璁紝Onconic灝嗘巿浜堝叕鍙鎬竴欏圭嫭瀹惰鍙紝鍏徃鍙湪璁稿彲鍖哄煙 (涓浗澶ч檰銆佷腑鍥介娓壒鍒鏀垮尯銆佷腑鍥芥境闂ㄧ壒鍒鏀垮尯鍙婁腑鍥藉彴婀懼湴鍖?/span>) 鍐呭紑鍙戙€佸埗閫犲拰鍟嗕笟鍖栭捑紱誨瓙绔炰簤鎬ч吀闃繪粸鍓?/span> (P-CAB) Zastaprazan (鍙堝悕涓?/span>JP-1366)銆?/span>

鍘熸枃銆婁附鐝犲尰鑽紩榪涙秷鍖栭亾鏂拌嵂Zastaprazan銆?/span>

縐戠爺淇℃伅

3鏈?/span>8鏃ワ紝嫻峰拰鑽墿瀹e竷錛屽叕鍙告棗涓嬩駭鍝佸彛鏈嶃€佸己鏁堛€侀珮閫夋嫨鎬х殑灝忓垎瀛?/span>MET鎶戝埗鍓傦紝鍖栬嵂1綾繪柊鑽搗鐩婂潶(璋風編鏇垮凹鐗?/span>)鑾峰緱鍥藉鑽搧鐩戠潱綆$悊灞€錛?/span>NMPA錛夋壒鍑嗗湪涓浗鑾峰緱闄勬潯浠舵壒鍑嗕笂甯傦紝鐢ㄤ簬娌葷枟鍏鋒湁闂磋川-涓婄毊杞寲鍥犲瓙錛?/span>MET錛夊鏄懼瓙14璺寵穬紿佸彉錛?/span>METex14璺沖彉錛夌殑灞€閮ㄦ櫄鏈熸垨杞Щ鎬ч潪灝忕粏鑳炶偤鐧岋紙NSCLC錛夋垚浜烘偅鑰呫€?/span>

鍘熸枃銆婃搗鍜岃嵂鐗?綾繪柊鑽胺緹庢浛灝肩墖鑾鋒壒涓婂競銆?/span>

緇堢甯傚満

浠?/span>2021騫村紑濮嬶紝鍥介噰鍓?/span>5鎵圭殑閮ㄥ垎鍝佺錛岀壒鍒槸閲囪喘鍛ㄦ湡涓?/span>1-2騫寸殑鍝佺錛屽紑濮嬪ぇ閲忚繘鍏ユ柊鐨勭畫綰﹂樁孌點€傛埅姝?/span>2022騫村簳錛屽浗閲囩1-5鎵癸紝榪涘叆緇害闃舵鐨勫搧縐嶆暟閲忓凡杈?/span>100涓紝鎸夌収褰撴椂鐨勪腑閫夌害瀹氶噰璐噾棰濅負76浜垮厓錛屽崰姣斿凡緇忚秴榪囦簡30%澶氥€傚叾涓浗閲囩涓€鎵瑰搧縐嶅凡緇忓叏閮ㄨ繘鍏ョ畫綰﹀懆鏈燂紝絎簩銆佷笁鎵瑰凡緇忚秴榪囧崐鏁拌繘鍏ョ畫綰﹀懆鏈熴€?/span>

鍘熸枃銆婅秴160浜垮厓瑙勬ā鐨勫浗閲囧搧縐嶅紑鍚畫綰︾珵浜夋柊鍛ㄦ湡銆?/span>

 

鏈湡鐩綍

鏀跨瓥娉曡    2

鍥藉姟闄㈠姙鍏巺鍗板彂銆婁腑鍖昏嵂鎸叴鍙戝睍閲嶅ぇ宸ョ▼瀹炴柦鏂規銆?/span> 2

鍥藉鑽洃灞€鍗板彂銆?/span>2023騫存楠岃兘鍔涢獙璇佽鍒掋€?/span>      2

鍥藉鍖諱繚灞€鍙戞枃 鎸佺畫鎵╁ぇ鑽搧闆嗛噰瑕嗙洊闈?/span>      3

鍥藉鍥涢儴闂ㄨ仈鍚堝嵃鍙戙€婃秹鍙婁漢鐨勭敓鍛界瀛﹀拰鍖誨鐮旂┒浼︾悊瀹℃煡鍔炴硶銆?/span>  4

鍥藉鍗敓鍋ュ悍濮旈€氭姤鐭己鑽搧淇濅緵紼充環鎯呭喌    4

鍥藉鍗仴濮斿彂甯冦€婂仴搴蜂腑鍥借鍔?/span>2023騫村伐浣滆鐐廣€?/span>    4

銆婂崟鑷備復搴婅瘯楠岀敤浜庢敮鎸佹姉鑲跨槫鑽笂甯傜敵璇風殑閫傜敤鎬ф妧鏈寚瀵煎師鍒欍€嬪彂甯?/span> 8

銆婃櫄鏈熷墠鍒楄吅鐧屼復搴婅瘯楠岀粓鐐規妧鏈寚瀵煎師鍒欍€嬪彂甯?/span>      8

琛屼笟瑙傚療    8

2022 騫村尰淇濈粺璁″揩鎶ユ潵浜嗭紝鍖諱繚鎬繪敮鍑?/span>24431.72浜垮厓      8

浠垮埗鑽竴鑷存€ц瘎浠峰弬姣斿埗鍓?/span>    10

絎叓鎵瑰浗閲囬渶瑕佸灝戝師鏂欒嵂錛岀瓟妗堝湪榪欓噷 19

2023騫存斂搴滃伐浣滄姤鍛婄粰鍖葷枟棰嗗煙鍒掗噸鐐?/span>    23

2023騫村尰鑽涓氫袱浼氫唬琛ㄦ彁妗堟眹鎬?/span>     26

浼佷笟鍔ㄦ€?/span>    27

緹庤開瑗?/span>2022騫村噣鍒╂鼎鍚屾瘮澧為暱榪戜笁鎴?/span>       27

鍜岄粍鍖昏嵂2022騫村害涓氱嘩錛氭€繪敹鍏?/span>4.264浜跨編鍏冿紝鍚屾瘮澧為暱20%      27

鑹懼姏鏂?/span>2022騫翠笟緇╁揩鎶ワ細鍑€鍒╂鼎鍚屾瘮澧為暱 627.68 %   28

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鐧炬祹紲炲窞2022騫翠笟緇╁揩鎶ワ細钀ユ敹鍚屾瘮涓婂崌26.1%  28

鎮﹀悍鑽笟2022騫翠笟緇╁揩鎶ワ細鍑€鍒╂鼎3.38浜垮厓 鍚屾瘮闄?/span>38%       28

鏂板拰鎴?/span>2022騫翠笟緇╁揩鎶ワ細鍑€鍒╂鼎鍚屾瘮涓嬮檷15.51%       29

涓婂競浼佷笟閫氳繃浠垮埗鑽竴鑷存€ц瘎浠瘋嵂鐗╋紙2023騫?/span>2鏈?/span>21-3鏈?/span>17鏃ワ級      29

绔嬫柟鍒惰嵂鎷熷嚭鍞珛鏂硅嵂涓氭帶鍒舵潈 闆嗕腑浼樺娍璧勬簮鑱氱劍鍖昏嵂鍒墮€犱笟     30

鐧懼ゥ娉版嫙瀹氬鍕熻祫16.4浜垮厓鍔犵爜鐮斿彂 30

鍗氳吘鍒跺墏宸ュ巶瀹屾垚棣栦釜涓瘯欏圭洰鐢熶駭  31

鍦e厗鑽墿鎷熸姇寤哄勾浜?/span>1000涓囧墏楂樼澶嶆潅娉ㄥ皠鍓傞」鐩?/span>    31

鑹懼姏鏂紩榪涘拰瑾夊尰鑽柊涓€浠?/span>EGFR鎶戝埗鍓?/span>   32

鑽煶縐戞妧鎷熸姇璧?/span>12浜垮緩璁懼垱鏂拌嵂鐗╁伐鑹哄紑鍙戝強涓瘯騫沖彴   32

鍗庨偊鍋ュ悍鎶曡祫1浜垮厓鎴愮珛瀛愬叕鍙?/span>   33

姝ラ暱鍒惰嵂鎶曡祫杞戒綋鑽墿寮€鍙戝晢闀跨澘鐢熺墿     33

鍜岄粍鍖昏嵂涓庢鐢扮殑鍛嬪柟鏇垮凹涓浗浠ュ鍦板尯璁稿彲鍗忚宸插畬鎴愪氦鏄?/span>       33

楂樻祹鍖葷枟涓庡崕娑︿笁涔濅婦琛屾垬鐣ヤ氦嫻佷細 鐩撮潰鍖昏嵂闆跺敭琛屼笟鏈潵鏈洪亣鍜岄棶棰?/span>   33

涓界彔鍖昏嵂寮曡繘娑堝寲閬撴柊鑽?/span>Zastaprazan  34

鐭寵嵂闆嗗洟瀛愬叕鍙歌幏嫻峰叧淇$敤綆$悊鏈€楂樼瓑綰ц璇?/span>       34

鑻戜笢鐢熺墿涓庢垚閮藉厛瀵兼垚绔嬪悎璧勫叕鍙革紝鎼烘墜鎵撻€犲皬鏍擱吀鑽墿CDMO鏈嶅姟騫沖彴 35

縐戠爺淇℃伅    36

2023騫?/span>01鏈堢編FDA鎵瑰噯鐨勬柊鑽?/span>    36

杈夌憺鏂板瀷榧誨柗鍓?/span>Zavzpret錛?/span>ZAVEGEPANT錛夊湪緹庤幏鎵逛笂甯?/span>      37

闆風壒緇煎悎寰侀嬈捐嵂鐗╋紒Daybue(trofinetide)鍦ㄧ編鑾鋒壒       37

浜垮竼鍖昏嵂鎷夎€冩矙鑳烘敞灝勬恫鑾鋒壒涓婂競      38

嫻峰拰鑽墿1綾繪柊鑽胺緹庢浛灝肩墖鑾鋒壒涓婂競     38

鐩婃櫘鐢熷弻緹熻悩閰告洸鏅憺鏋楀湪涓浗鑾鋒壒鏂伴€傚簲鐥?/span>       38

鎭掔憺PDL1鍗曟姉闃垮緱璐濆埄鍗曟姉娉ㄥ皠娑插湪鍗庤幏鎵逛笂甯?/span> 39

嫻鋒鑽笟鏇插Ε鐝犲崟鎶楃敓鐗╃被浼艱嵂鑾鋒壒涓婂競 39

鎭掔憺鍖昏嵂ADC鐤楁硶SHR-A1811鎷熺撼鍏ョ獊鐮存€ф不鐤楀搧縐?/span> 40

鐖卞痙紼嬪尰鑽?/span>AL8326鐗囨嫙紿佺牬鎬ф不鐤楀搧縐?/span>   40

澶嶅畯姹夐湒鎶楄偪鐦ゅ崟鎶?/span>HLX51鍥藉唴鑾鋒壒涓村簥 41

榪滃ぇ鍖昏嵂鍏ㄧ悆鍒涙柊RDC鑽墿ITM-11鍥藉唴鑾鋒壒涓村簥 41

榪堝崥鑽笟:鏍稿績浜у搧CMAB009涓婂競鐢寵鑾峰彈鐞?/span> 41

嫻鋒€濈鍒涙柊鑽?/span>HSK40118鐗囪幏鎵逛復搴?/span>    42

鐭寵嵂闆嗗洟鎭╂湕鑻忔嫓鍗曟姉涓婂競鐢寵鑾峰彈鐞?/span>     42

緇堢甯傚満    42

鍥介噰鍝佺鍦ㄧ畫綰︾珵浜変腑鐨勯噺浠鋒定璺屽彉騫?/span>     42

瓚?/span>160浜垮厓瑙勬ā鐨勫浗閲囧搧縐嶅紑鍚畫綰︾珵浜夋柊鍛ㄦ湡   47

渚濇墭涓棿浣撲紭鍔?/span> 鎴戝浗鑾タ娌欐槦緇х畫鍙戝姏涓嬫父甯傚満 51

鍖昏嵂鍘熸枡    53

2022騫寸淮鐢熺礌A甯傚満浠鋒牸鈥滆叞鏂╁啀鏂┾€濊錘鏄撻閿愬噺涓€鍗?/span>    53

鍗板害鐮旇鍘熸枡鑽?/span>API甯傚満鍚堣瓚嬪娍鍜屾櫤鑳藉墠鏅?/span> 55

鎵戠儹鎭棝鍘熸枡鑽緵搴旂紦瑙o紝鍘傚鐪嬭鍗曞ぇ灝忔姤浠?/span>   56

榪炵畫鍙嶅簲鎶€鏈紑鍙戝拰搴旂敤鏈夊嚑瀹?/span>   56

鐪嬫帓鍚嶏紝鎵懼晢鏈衡€斺€旂畝璇?/span>2022騫村嵃搴﹀師鏂欒嵂T50浜у搧       58

鍏ㄧ悆娌欏潶綾諱駭涓氶摼榫欒薄鍏辮垶錛岄泦閲囩偣鐕冨競鍦烘嫇灞曟柊鍔ㄥ姏     61

鏅埄鍒惰嵂鐩愰吀鑳虹閰師鏂欒嵂鑾?/span>CEP璇佷功     63

浜垮竼鍖昏嵂鈥滈噸閰掔煶閰稿幓鐢茶偩涓婅吅绱犫€濆師鏂欒嵂涓婂競鐢寵鑾鋒壒鍑?/span>    63

娌沖崡鍗庡晢鑽笟鎶曡祫2.6浜垮厓鎶€鏀規柊澧炴矙鍧︾被鍘熸枡鑽」鐩?/span>      64

灞變笢鑹炬牸鏋楀埗鑽姇璧勪竴鏈?/span>3.3浜垮厓鏂板緩14縐嶅師鏂欒嵂欏圭洰    64

鍗庝粊鑽笟鎶曡祫榪?/span>6000涓囧厓寤鴻楂樼鍘熸枡鑽」鐩?/span>10涓駭鍝佷緵鑷敤   66

婀栧崡涔濆吀瀹忛槼鍒惰嵂鎶曡祫2.6浜垮厓鏂版墿寤哄師鏂欒嵂鍙婅嵂鐢ㄨ緟鏂欑豢鑹叉櫤鑳界敓浜у熀鍦伴」鐩?/span>     66

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